Host: TUG; Supervisor: Torsten Mayr
The overall objective of this PhD study is the development and test of sensor technology for the integration in the microfluidic toolbox and miniaturized bioreactor systems developed with other partners (DTU, TUB, TUG, UCL, Micronit, ChipShop, iX-factory, UNICZ, UOULU, nanoMyP). The ESR will be responsible for the adjustment of the sensor technology for monitoring different bioprocesses including cell culturing and biocatalysis.
Tasks and methodology
For sensor integration and application different strategies and formats are investigated including, sensor layers for monolithical integration, nano-sensor particles, magnetic nano-sensor particles and core-shell nanofibre mats. Herein the tasks of the ESR includes:
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Preparation and characterisation of sensor materials and composites for the various sensor formats.
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Optimisation of materials to the needs of the various application
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Integration of these sensors to microbioreactors
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Investigation of measurement-set ups for sensor read-out
Results
They are broken down according to Milestones and Deliverables
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Development, integration and testing sensor layers (WP8) to analyse oxygen transfer within microfermentation reactors
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Measurement set-up for parallel read-out of microbioreactors
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Microbioreactors with integrated optical sensors and IR probes for the application in biocatalytic screening toolbox (WP6) and biocatalysis (WP7)
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Nanosensor particles for monitoring biocatalytic screening toolbox (WP 6) and biocatalysis (WP7)
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Magnetic nano sensor particles for biocatalytic screening toolbox (WP6) and biocatalysis (WP7)
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Microbioreactors with integrated sensors tested in cultivation and biocatalysis
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Nano-sensor particles tested in cultivation (WP6) and biocatalysis (WP7)
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Magnetic nano-sensor particles tested in cultivation (WP6) and biocatalysis (WP7)